D-Mannitol Powder

High-Purity D-Mannitol Powder – Premium Pharmaceutical & Food Grade Ingredient

Avans NutriHealth Co., Ltd. is manufacturing pharmaceutical grade D-Mannitol Powder with strict international standards and is certified with FDA, Halal, BP, CP and FSSC22000. Our white crystalline powder is ≥98.0% (HPLC assay) pure and has a specific optical rotation tightly controlled at +23.0° to +25.0°, which ensures consistent bioavailability and processing stability. With our integrated group manufacturing capabilities and stringent quality control systems, we provide batch-to-batch reliability for this non-hygroscopic sugar alcohol excipient in pharmaceutical, food and beverage applications. We provide with technical support in the formulation creation process for businesses around the world that are looking for natural, safe, and functionally superior raw materials that are available in inventory and have CAS number 69-65-8 traceability.

Technical Specifications of D-Mannitol Powder

Our manufacturing entity maintains stringent quality parameters that exceed pharmacopeial requirements:

These controlled specifications ensure optimal solubility (approximately 216 g/L at 25°C in water) and thermal stability for diverse manufacturing processes.

Industrial Applications Across Multiple Sectors

Pharmaceutical Formulations 

Our pharmaceutical grade substance is a key tablet excipient with outstanding compressibility and rapid disintegration characteristics. Medical uses . It is used as an osmotic diuretic agent . It is used as a stabiliser in lyophilised injectable preparations .

Food & Beverage Manufacturing

It is used as a sugar substitute in sugar-free candies , giving 50-60% of the sweetness of sucrose with a nice cooling effect . It is used by beverage makers in powdered drink mixes for its non-caking flow characteristics and stability in acid pH.

Health Supplement Manufacturing 

It serves as a bulking agent and binder for nutraceutical capsules and tablets with a consistent dose accuracy. Preferred for complex recipes, compatible with sensitive active ingredients like probiotics and enzymes.

Core Functional Advantages

D-Mannitol Powder offers unique physiochemical properties distinguishing it from other polyols and excipients.

Its non-hygroscopic characteristic reduces caking during storage and processing even in humidity-controlled conditions over 40% RH. This feature gives a considerable shelf-life extension compared to sorbitol or xylitol.

The molecule is metabolised to a very little extent, with about 50 % passing intact via the gastrointestinal tract. This results in a low glycaemic index (GI=0) which is perfect for diabetic friendly formulations as it does not affect blood glucose.

Heat stability up to 160°C allows incorporation into high temperature industrial processes such as tablet compression, hard candy making and spray-drying applications without degradation or discolouration.

Storage & Handling Recommendations

Store in tightly closed containers in cool, dry warehouses at temperatures not exceeding 25 °C. Non hygroscopic however extended exposure to humidity > 60% RH should be avoided.

Multi-layer kraft paper bags with inner polyethylene liners or fibre drums with desiccant sachets are recommended packing. We offer standard packaging choices from 25kg bags up to bulk containers, depending on the order volume.

Typical shelf life is 36 months from date of manufacture when stored under prescribed conditions . Regular quality monitoring every 12 months assures ongoing conformance to standards.

Quality Assurance & Manufacturing Excellence

Avans NutriHealth guarantees traceability from raw material sourcing to final packaging with integrated supply chain management. Our professional R&D team performs pre-shipment testing including microbiological screening for the absence of Salmonella, E. coli and Staphylococcus aureus.

We track all production batches with our detailed COA. We keep our manufacturing facilities at a relative humidity of less than 45% and a temperature of 15-25°C to prevent the absorption of moisture.

Our commitment to food safety management systems is shown by our FSSC22000 certification. We continuously monitor our crucial control points to maintain a contamination-free production process in accordance with worldwide GMP standards.

FAQ

Q: What is the main difference between D-Mannitol and sorbitol in pharmaceutical applications?

A: D-Mannitol is preferred for moisture sensitive formulations because of its better non-hygroscopic characteristics and reduced solubility. It also delivers superior mouth-feel with the characteristic cooling effect in chewable pills.

Q: Can your product be used in organic certified products?

A: Our regular manufacturing technique is not organic certified. However, we will discuss particular sourcing requirements for corn-derived fermentation techniques eligible for organic applications, upon request.

Q: What are the direct compression tableting properties of D-Mannitol?

A: We have a particle size distribution of 40-80 mesh that is highly flowable and compressible. Typical binding ratios are 5-20% depending upon the characteristics of the active ingredient. Technical assistance on optimisation of formulation.

Q: What documentation do you provide for regulatory submissions?

A: Complete regulatory support packages include Certificate of Analysis, manufacturing flowcharts, allergen statements, BSE/TSE declarations, GMO-free certifications, and stability data. Additional documentation can be provided per customer requirements.

Q: Is there risk of cross-contamination with allergens in your facility?

A: Our dedicated production lines for sugar alcohols maintain strict segregation protocols. Comprehensive allergen control programs with regular environmental monitoring ensure allergen-free status for major allergens including gluten, dairy, soy, and nuts.

Partner With Avans NutriHealth Today

Contact our team at Lillian@avansnutri.com to request D-Mannitol Powder samples, technical data sheets, or discuss your specific formulation requirements.