Silicified Microcrystalline Cellulose Powder
Appearance: white or almost white powder
Origin: China
Stocks: in stock
Certificate: GMP, FSC, ISO,USDA, HACCP, FSSC22000,HALAL,etc.
CAS no: 9004-34-6 112945-52-5
Application: pharmaceutical, used as a filler in tablets and capsules.
- Product Description
Silicified Microcrystalline Cellulose Powder – Premium Pharmaceutical Excipient
Avans NutriHealth Co., Ltd. is a high-grade Silicified Microcrystalline Cellulose Powder manufacturer, and its production entity is Avans (Qingdao) NutriHealth Technology Co., Ltd. This medicinal excipient is a mixture of microcrystalline cellulose and colloidal silicon dioxide providing improved flowability and compressibility. Our SMCC series guarantees a particle size distribution of 50-180μm, ensuring a uniform tablet hardness over 8kp and disintegration time below 15 minutes. Our product is certified by GMP, ISO, HACCP, FSSC22000, HALAL and USDA standards and fulfils the strict worldwide pharmaceutical demands. We provide technical and quality assurance support for your formulation needs with consistent inventory availability and reliable supply chain management.
What Is Silicified Microcrystalline Cellulose?
This excipient is a unique kind of microcrystalline cellulose combined with silicon dioxide. The silicification procedure results in a significant improvement of the flow characteristics compared to normal cellulose materials.
This white to near white powder is useful for direct compression tablet manufacture. The hybrid structure possesses the binding property of cellulose and the glidant property of silica.
The material has good stability under different humidity conditions. Reduce equipment wear and ensure uniformity of processing parameters in your production environment.
Technical Specifications
Parameter | Specification |
Appearance | White or almost white powder |
CAS Number | 9004-34-6, 112945-52-5 |
Origin | China |
Loss on Drying | ≤7.0% |
pH Value | 5.0-7.5 |
Bulk Density | 0.30-0.45 g/mL |
Particle Size | 50-180 μm (customizable) |
Heavy Metals | <10 ppm |
Microbiology | Total Plate Count <1,000 CFU/g |
Key Applications in Pharmaceutical Manufacturing
Tablet Production: Your formulation team will appreciate the exceptional direct compression qualities. This excipient can often eliminate the need for wet granulation and thereby reduce production time and costs.
Capsule Filling: Uniform fill weights due to enhanced flow properties. In most formulations, you can get uniform dosage without the inclusion of glidants.
Controlled Release Systems: This substance is a good matrix forming to achieve controlled medication release patterns. It gives structural integrity, yet predictable patterns of disintegration.
The substance is also suitable for use in sachet and oral suspension formulations. This adaptable excipient offers extra flexibility in your product development.
Manufacturing Advantages for Your Production Line
The flow of silicified microcrystalline cellulose powder increases the efficiency of your production process. The silicification decreases bridging and rat-holing in hoppers and maintains the consistent feed rates of the material.
Significant reduction of tablet weight variability as compared to normal cellulose. You will witness a more strict control of crucial quality attributes during high speed compression.
Reduced ejection forces Protect your punches and kills. This means lower maintenance cost and longer life term of your equipment.
The material can be reworked easily. This excipient maintains its functional qualities throughout several compression cycles when rejected tablets have to be recycled.
Resistant to moisture and will not cake on storage. Stable material handling features all year round make your warehousing operations easy.
Quality Assurance and Compliance
Our manufacturing plant is fully GMP compliant and is subject to frequent 3rd party audits. Each batch of manufacturing is subjected to strict identity tests using FTIR and microscopic analysis.
Receive comprehensive paperwork including Certificates of Analysis, Safety Data Sheets and regulatory support files. Our quality control laboratory is validated for USP, EP and JP test procedures.
FSC accreditation assures that raw cellulose materials are sourced responsibly. You may confidently report your supplier chain’s sustainability needs.
By having the HALAL certification you can reach out to markets that need religious compliance. We are USDA certified to help with organic formulation development as needed.
FAQ
Q: Is silicified microcrystalline cellulose safe for consumption?
A: Yes, this material is generally recognized as safe (GRAS) by regulatory authorities worldwide. It passes through the digestive system without being absorbed, functioning as dietary fiber. The combination with silicon dioxide maintains the same safety profile as standard cellulose, as both components are well-established pharmaceutical excipients with decades of safe use.
Q: What makes silicified versions better than standard microcrystalline cellulose?
A: The silicification process adds 2-10% colloidal silicon dioxide, dramatically improving flow properties and reducing electrostatic charge. You'll experience 40-60% better flow rates and lower lubricant requirements. This means faster production speeds and fewer coating defects in your finished tablets.
Q: Can this excipient work with moisture-sensitive active ingredients?
A: Absolutely. The low moisture content (typically below 5%) and excellent moisture buffering capacity protect hygroscopic APIs. You can process and store formulations with greater stability compared to higher-moisture excipients. The material also demonstrates minimal moisture uptake under standard storage conditions.
Q: What particle size should I specify for my application?
A: For direct compression tablets, 50-180μm provides optimal performance. If you're developing orally disintegrating tablets, finer grades (20-90μm) offer faster disintegration. Our technical team can recommend specific grades based on your drug load, tablet size, and hardness requirements.
Q: How does this compare to spray-dried lactose or dicalcium phosphate?
A: The product offers superior compressibility at lower compression forces. Unlike lactose, it contains no reducing sugars that could react with amine-containing drugs. Compared to dicalcium phosphate, it provides better disintegration and requires less lubricant, improving dissolution profiles.
Contact Us for Your Formulation Needs
Ready to enhance your tablet formulation with premium Silicified Microcrystalline Cellulose Powder? Contact us today at Lillian@avansnutri.com to discuss your requirements.
