Can berberine help with weight loss?
There is some evidence that berberine may influence body mass index (BMI), as well as cholesterol and blood sugar.
Can berberine help with weight loss?
A 2020 review of previous laboratory, animal, and human studies found some evidence that berberine may influence biological processes that can aid weight loss and overall metabolic health.
The authors found that berberine:
reduces blood glucose
increases GLP-1, GLP-2, and peptide YY, which are substances that regulate metabolism and appetite
may “switch off” genes that are responsible for cholesterol absorption
The authors conclude that berberine may show promise for treating or preventing metabolic conditions, such as overweight or obesity. They also suggest it may help prevent diabetes.
However, whether berberine safely and reliably causes weight loss in humans is still unclear. A 2020 review of randomized controlled trials found that while the compound seemed to reduce BMI and waist circumference, it did not significantly reduce overall body weight.
BMI measures a person’s weight in comparison to their height and age, whereas body weight is a person’s total weight.
While some studies have found a beneficial effect, not all have. Berberine has low bioavailability, meaning the body does not absorb it easily.
More research is necessary to confirm the results, correct dosage, and safety of berberine.
What are the other benefits of berberine?
Berberine does not have approval for treating any medical conditions in the U.S.
But past research suggestsTrusted Source berberine could help prevent:
atherosclerosis, where the arteries become narrow, increasing the risk of heart attack and stroke
type 2 diabetes
cardiovascular complications
neurological conditions
cancer
Berberine may also helpTrusted Source lower blood pressure in combination with amlodipine, which is a calcium channel blocker medication for high blood pressure.
Other sources note that berberine may beTrusted Source beneficial for treating symptoms of arthritis.
Summary
Berberine is a naturally occurring plant compound that companies sell as a dietary supplement. It has traditional medicinal uses, and people use it for several health reasons. Some take it to aid weight loss.
Although research is ongoing, several studies have found that taking berberine can help people lose weight. Research also indicates that it may have beneficial effects on several health conditions, such as type 2 diabetes.
It is advisable to speak with a healthcare professional before taking berberine. It may interact with some medications, and pregnant people and infants should not take berberine.
Medically reviewed by Janelle Duah, MD — Written by Ben Koprowski — Updated on January 22, 2025
